MRgFUS and Deep Brain Stimulation (DBS) are two primary interventional methods used in the treatment of movement disorders. While both aim to control symptoms such as tremors, they differ significantly in their mechanisms of action, permanence, and long-term management approaches.

Mechanism of Action: Lesion vs. Modulation

MRgFUS works by creating a controlled and permanent lesion in the targeted area of the brain. This effect is anatomical and irreversible. DBS, on the other hand, does not create a lesion; it modulates brain circuits through electrical stimulation. Its effect is functional and adjustable. This distinction forms the fundamental difference between the two methods.

Reversibility and Permanence

One of the most important features of DBS is that it is reversible. Stimulation settings can be modified over time, and the system can be turned off if necessary. This allows for adaptation to the progression of the disease. MRgFUS is a single-session, permanent intervention. In the right patient, this permanence can be a major advantage; however, it requires an exceptionally careful decision-making process.

Long-Term Management and Repeatability

In DBS, it is common and expected for stimulation settings to be adjusted as the disease progresses. Re-intervention is possible if needed. In MRgFUS, there is no "repetition" in the traditional sense; the effect is fixed. However, if the disease progresses or new symptoms emerge, additional treatment options may be considered.

Consequently, while DBS stands out for long-term management in patients with progressive and multidimensional symptoms, MRgFUS is evaluated as a method for patients with a more stable clinical profile and a prominent, dominant symptom, which is excessive tremor.

M adjustable treatment method.

Both paths yield significant results when chosen for the right patient at the right time. The treatment plan should always be shaped by personalized evaluation and long-term foresight.

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